{"id":793,"date":"2020-09-18T12:53:42","date_gmt":"2020-09-18T09:53:42","guid":{"rendered":"https:\/\/f-genetics.com\/?post_type=test&#038;p=793"},"modified":"2026-01-23T21:23:15","modified_gmt":"2026-01-23T18:23:15","slug":"pgt","status":"publish","type":"test","link":"https:\/\/f-genetics.com\/en\/pgt\/","title":{"rendered":"PGT-A"},"content":{"rendered":"<div class=\"wp-block-genetics-row-with-tabs test__row\"><div class=\"test__col\"><section class=\"test__tabs\"><h2>What is PGT-A<\/h2><div class=\"inner\">\n<div class=\"wp-block-genetics-tabs c-tabs\"><div class=\"c-tabs__nav\"><div class=\"tabs-wrapper swiper-wrapper\"><div data-tab=\"1\" class=\"tab-link swiper-slide current\" tabindex=\"0\">What is PGT-A<\/div><div data-tab=\"2\" class=\"tab-link swiper-slide\" tabindex=\"0\">Indications<\/div><div data-tab=\"3\" class=\"tab-link swiper-slide\" tabindex=\"0\">The method<\/div><div data-tab=\"4\" class=\"tab-link swiper-slide\" tabindex=\"0\">Test result<\/div><div data-tab=\"5\" class=\"tab-link swiper-slide\" tabindex=\"0\">Quality control<\/div><\/div><\/div><div class=\"tabs-arrow arrow-prev\">\u2190<\/div><div class=\"tabs-arrow arrow-next\">\u2192<\/div><div class=\"c-tabs__contents\">\n<div class=\"wp-block-genetics-tab tab-content genetics-tab-1 current\">\n<div class=\"row\">\n<div class=\"col col-6\">\n<p>PGT-A, or preimplantation genetic testing for aneuploidy, is the screening of embryos in an assisted reproductive technology cycle for chromosomal abnormalities before they are transferred into the uterus to increase the chances of achieving a successful pregnancy.<\/p>\n\n\n\n<p><strong>PGT-A detects:<\/strong><\/p>\n\n\n\n<div class=\"row\">\n<div class=\"col col-6\">\n<ul class=\"wp-block-genetics-list genetics-list has-14-font-size\">\n<li>Aneuploidy<\/li>\n\n\n\n<li>Partial (segmental) aneuploidy<\/li>\n\n\n\n<li>Unbalanced translocations<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"col col-4\">\n<ul class=\"wp-block-genetics-list genetics-list has-14-font-size\">\n<li>Certain types of polyploidy<\/li>\n\n\n\n<li><a href=\"https:\/\/f-genetics.com\/en\/mozaiczizm\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mosaicism<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"col col-4\">\n<p class=\"is-style-yellow has-14-font-size\">Many factors influence the course of a pregnancy, but the most common cause of an unfavourable outcome is chromosomal abnormalities.<\/p>\n\n\n<p><span class=\"factoid\"><span>38%\u201376%<\/span>the prevalence of chromosomal abnormalities detected in spontaneous abortion, according to world and Russian statistics <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-genetics-tab tab-content genetics-tab-2\">\n<h3 class=\"is-style-24-b wp-block-heading\">Indications for the test<\/h3>\n\n\n\n<div class=\"row\">\n<div class=\"col col-5\">\n<ul class=\"wp-block-genetics-list genetics-list has-16-font-size\">\n<li>Late reproductive age for women \u2014 35 years and older<\/li>\n\n\n\n<li>Convulsive miscarriage (2 or more spontaneous abortions in the past)<\/li>\n\n\n\n<li>Repeated implantation failure (3 failed transfers in women under 35 years old and 2 in women of 35 and older)<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"col col-5\">\n<ul class=\"wp-block-genetics-list genetics-list has-16-font-size\">\n<li>Severe spermatogenesis disorders in men (oligoasthenozoospermia, oligozoospermia, azoospermia)<\/li>\n\n\n\n<li>Carrying balanced chromosomal rearrangements (Robertsonian translocation, certain reciprocal translocations and inversions as well as other numerical and structural chromosomal anomalies).<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<p class=\"is-style-purple\">In all of these patient groups, an increased incidence of chromosomal abnormalities in embryos is suspected.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-genetics-tab tab-content genetics-tab-3\">\n<h3 class=\"is-style-24-b wp-block-heading\">Methodology of the test<\/h3>\n\n\n\n<div class=\"row\">\n<div class=\"col col-6\">\n<p>At First Genetics, we perform PGT-A using NGS (Next Generation Sequencing). NGS allows the most accurate and fastest selection of embryos without chromosomal abnormalities for transfer.<\/p>\n\n\n\n<p>The NGS method allows all chromosomes of the embryo to be analysed to detect mosaicism and unbalanced chromosomal rearrangements. <a href=\"https:\/\/f-genetics.com\/en\/mozaiczizm\/\" target=\"_blank\" rel=\"noreferrer noopener\">mosaicism<\/a> \u0438&nbsp;\u043d\u0435\u0441\u0431\u0430\u043b\u0430\u043d\u0441\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u0445\u0440\u043e\u043c\u043e\u0441\u043e\u043c\u043d\u044b\u0435 \u043f\u0435\u0440\u0435\u0441\u0442\u0440\u043e\u0439\u043a\u0438.<\/p>\n<\/div>\n\n\n\n<div class=\"col col-4\">\n<p class=\"has-14-font-size\">Using PGT-A in an IVF cycle can significantly reduce the risk of implantation failure, pregnancy loss and increase the chances of delivering a healthy child.<\/p>\n<\/div>\n<\/div>\n\n\n\n<dl class=\"wp-block-genetics-instruction test__instruction\">\n<div class=\"wp-block-genetics-instruction-item step\"><div class=\"icon\"><img decoding=\"async\" src=\"https:\/\/f-genetics.com\/wp-content\/uploads\/2020\/09\/pgt-method-1.svg\" alt=\"\"\/><\/div><div class=\"text\"><div class=\"heading\">Cultivation of embryo cells<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-genetics-instruction-item step\"><div class=\"icon\"><img decoding=\"async\" src=\"https:\/\/f-genetics.com\/wp-content\/uploads\/2020\/09\/pgt-method-2.svg\" alt=\"\"\/><\/div><div class=\"text\"><div class=\"heading\">Trophectoderm biopsy at the blastocyst stage<\/div>\n<p>A biopsy needle is used to collect cells for analysis. The cells are then sent to the laboratory for testing.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genetics-instruction-item step\"><div class=\"icon\"><img decoding=\"async\" src=\"https:\/\/f-genetics.com\/wp-content\/uploads\/2020\/09\/pgt-method-3.svg\" alt=\"\"\/><\/div><div class=\"text\"><div class=\"heading\">Whole genome amplification<\/div>\n<p>Whole genome amplification (WGA) and library preparation for chip mapping.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genetics-instruction-item step\"><div class=\"icon\"><img decoding=\"async\" src=\"https:\/\/f-genetics.com\/wp-content\/uploads\/2020\/09\/pgt-method-4.svg\" alt=\"\"\/><\/div><div class=\"text\"><div class=\"heading\">Ion Semiconductor Sequencing<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-genetics-instruction-item step\"><div class=\"icon\"><img decoding=\"async\" src=\"https:\/\/f-genetics.com\/wp-content\/uploads\/2020\/09\/pgt-method-5.svg\" alt=\"\"\/><\/div><div class=\"text\"><div class=\"heading\">Bioinformatics analysis<\/div>\n<p><a href=\"https:\/\/f-genetics.com\/en\/pgt-bioinformaticheskij-analiz\/\">Learn more about bioinformatics data analysis<\/a><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genetics-instruction-item step\"><div class=\"icon\"><img decoding=\"async\" src=\"https:\/\/f-genetics.com\/wp-content\/uploads\/2020\/09\/pgt-method-6.svg\" alt=\"\"\/><\/div><div class=\"text\"><div class=\"heading\">Test result<\/div>\n<p>Forming a conclusion on the basis of the obtained data.<\/p>\n<\/div><\/div>\n<\/dl>\n\n\n\n<p class=\"is-style-purple\"><a href=\"https:\/\/f-genetics.com\/wp-content\/uploads\/2020\/09\/pgt-\u2014-primer-rezultata.pdf\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Download a sample PGT-A result<\/strong><\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-genetics-tab tab-content genetics-tab-4\">\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/f-genetics.com\/wp-content\/uploads\/2021\/11\/pgt-a1_en.svg\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"735\" src=\"https:\/\/f-genetics.com\/wp-content\/uploads\/2021\/11\/pgt-a1_en.svg\" alt=\"\" class=\"wp-image-4961\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<div class=\"row\">\n<div class=\"col col-4\"><p><span class=\"factoid\"><span>Up to 70%<\/span>of embryos contain chromosomal abnormalities (numerical or structural)<\/span><\/p>\n<\/div>\n\n\n\n<div class=\"col col-6\">\n<p>As the age of the mother increases, the proportion of embryos with chromosomal abnormalities increases significantly and the likelihood of a successful IVF attempt without genetic testing decreases significantly.<\/p>\n\n\n\n<p>Such aneuploid embryos can be selected for transfer because they are not visually different from embryos without chromosomal abnormalities.<\/p>\n<\/div>\n<\/div>\n\n\n<p><span class=\"factoid\"><span>On day 3-5<\/span>the embryo is biopsied from the trophectoderm cells and PGT-A is performed<\/span><\/p>\n\n\n\n<p>PGT-A identifies and selects an embryo without chromosomal abnormalities, which increases the chances of implantation and pregnancy.<\/p>\n\n\n\n<p>Statistically, pregnancies with the help of ART occur in about 30-40% of cases.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-genetics-tab tab-content genetics-tab-5\">\n<h3 class=\"is-style-24-b wp-block-heading\">Quality control at every stage of the test:<\/h3>\n\n\n\n<div class=\"row\">\n<div class=\"col col-3\">\n<p><strong>Pre-analytical<\/strong><\/p>\n\n\n\n<p>Conducting test biopsies, monitoring compliance with transport and storage regimes<\/p>\n<\/div>\n\n\n\n<div class=\"col col-3\">\n<p><strong>Analytical<\/strong><\/p>\n\n\n\n<p>Minimisation of errors through a more user-friendly protocol for merging and cleaning libraries, automation of sample preparation<\/p>\n<\/div>\n\n\n\n<div class=\"col col-3\">\n<p><strong>Post-analytical<\/strong><\/p>\n\n\n\n<p>Independent interpretation and data analysis by three specialists, minimising subjective decisions \u2014 developing and training a neural network.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div><\/section><\/div>\t<div class=\"test__aside\">\n\t\t<div class=\"test__links\" id=\"docs\"> \n\t\t\t\t\t\t\t<div><a class=\"doc-link\" href=\"https:\/\/f-genetics.com\/wp-content\/uploads\/2020\/09\/f-genetics-\u2014-pgt.pdf\" target=\"_blank\"><img decoding=\"async\" src=\"https:\/\/f-genetics.com\/wp-content\/themes\/genetics\/img\/icons\/pdf_purple.svg\" alt=\"\"><span>The importance of screening embryos for chromosomal abnormalities  <i>3 MB, PDF<\/i><\/span><\/a><\/div>\n\t\t\t\t\t\t\t<div><a class=\"doc-link\" href=\"https:\/\/f-genetics.com\/wp-content\/uploads\/2020\/09\/pgt-a-metodom-ngs-\u2014-ot-chego-zavisit-razreshenie-metoda_.pdf\" target=\"_blank\"><img decoding=\"async\" src=\"https:\/\/f-genetics.com\/wp-content\/themes\/genetics\/img\/icons\/pdf_purple.svg\" alt=\"\"><span>PGT-A with the NGS method. What does the authorization of the method depend on? (ru) <i>9 MB, PDF<\/i><\/span><\/a><\/div>\n\t\t\t\t\t\t\t<div><a class=\"doc-link\" href=\"https:\/\/f-genetics.com\/wp-content\/uploads\/2022\/03\/dogovor-pgt-a_oferta.pdf\" target=\"_blank\"><img decoding=\"async\" src=\"https:\/\/f-genetics.com\/wp-content\/themes\/genetics\/img\/icons\/pdf_purple.svg\" alt=\"\"><span>Contract  <i>824 KB, PDF<\/i><\/span><\/a><\/div>\n\t\t\t\t\t\t\t<div><a class=\"doc-link\" href=\"https:\/\/f-genetics.com\/wp-content\/uploads\/2022\/03\/fg-razreshenie.pdf\" target=\"_blank\"><img decoding=\"async\" src=\"https:\/\/f-genetics.com\/wp-content\/themes\/genetics\/img\/icons\/pdf_purple.svg\" alt=\"\"><span>Permission to carry out medical activities <i>741 KB, PDF<\/i><\/span><\/a><\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t\t<div> \n\t\t\t\t\t<button class=\"btn purple open-popup-link\" data-mfp-src=\"#ask-question-popup\">Ask a question<\/button>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<p><\/p>","protected":false},"template":"","class_list":["post-793","test","type-test","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.8 - 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