Cultivation of embryo cells
PGT-A
Free delivery across Russia
25 000 ₽
Available on credit
Available on credit
PGT-A
Embryo screening during IVF to increase the chances of successful implantation, pregnancy and birth.
Free delivery
From anywhere in Russia
Flexible deadlines
1.5 calendar days
(upon agreement)
7 calendar days
12 working days
Biopsy control
Lab partners undergo a test biopsy
Independent interpretation
The final result is reviewed by three of our experts
What is PGT-A
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PGT-A, or preimplantation genetic testing for aneuploidy, is the screening of embryos in an assisted reproductive technology cycle for chromosomal abnormalities before they are transferred into the uterus to increase the chances of achieving a successful pregnancy.
PGT-A detects:
- Aneuploidy
- Partial (segmental) aneuploidy
- Unbalanced translocations
- Certain types of polyploidy
- Mosaicism
Many factors influence the course of a pregnancy, but the most common cause of an unfavourable outcome is chromosomal abnormalities.
38%–76%the prevalence of chromosomal abnormalities detected in spontaneous abortion, according to world and Russian statistics
Indications for the test
- Late reproductive age for women — 35 years and older
- Convulsive miscarriage (2 or more spontaneous abortions in the past)
- Repeated implantation failure (3 failed transfers in women under 35 years old and 2 in women of 35 and older)
- Severe spermatogenesis disorders in men (oligoasthenozoospermia, oligozoospermia, azoospermia)
- Carrying balanced chromosomal rearrangements (Robertsonian translocation, certain reciprocal translocations and inversions as well as other numerical and structural chromosomal anomalies).
In all of these patient groups, an increased incidence of chromosomal abnormalities in embryos is suspected.
Methodology of the test
At First Genetics, we perform PGT-A using NGS (Next Generation Sequencing). NGS allows the most accurate and fastest selection of embryos without chromosomal abnormalities for transfer.
The NGS method allows all chromosomes of the embryo to be analysed to detect mosaicism and unbalanced chromosomal rearrangements. mosaicism и несбалансированные хромосомные перестройки.
Using PGT-A in an IVF cycle can significantly reduce the risk of implantation failure, pregnancy loss and increase the chances of delivering a healthy child.
Trophectoderm biopsy at the blastocyst stage
A biopsy needle is used to collect cells for analysis. The cells are then sent to the laboratory for testing.
Whole genome amplification
Whole genome amplification (WGA) and library preparation for chip mapping.
Ion Semiconductor Sequencing
Bioinformatics analysis
Test result
Forming a conclusion on the basis of the obtained data.
Up to 70%of embryos contain chromosomal abnormalities (numerical or structural)
As the age of the mother increases, the proportion of embryos with chromosomal abnormalities increases significantly and the likelihood of a successful IVF attempt without genetic testing decreases significantly.
Such aneuploid embryos can be selected for transfer because they are not visually different from embryos without chromosomal abnormalities.
On day 3-5the embryo is biopsied from the trophectoderm cells and PGT-A is performed
PGT-A identifies and selects an embryo without chromosomal abnormalities, which increases the chances of implantation and pregnancy.
Statistically, pregnancies with the help of ART occur in about 30-40% of cases.
Quality control at every stage of the test:
Pre-analytical
Conducting test biopsies, monitoring compliance with transport and storage regimes
Analytical
Minimisation of errors through a more user-friendly protocol for merging and cleaning libraries, automation of sample preparation
Post-analytical
Independent interpretation and data analysis by three specialists, minimising subjective decisions — developing and training a neural network.
PGT-A at First Genetics
Technology
The NGS method analyses all chromosomes of the embryo and detects mosaicism and unbalanced chromosomal rearrangements
Specialists
Years of experience in genetics, laboratory diagnostics and bioinformatics
Confidentiality
All data is strictly confidential and cannot be passed on to third parties
Consulting
You can get an online consultation regarding the results of test
Security
Extensive control at each stage of testing
Free delivery
Free delivery of biomaterial across Russia
PGT-A
Any of our partner clinics provides a PGT service, which is carried out in the First Genetics laboratory.
Call us if you have any questions:
8 (800) 201 83 46
8 (800) 201 83 46
